Fig. 1 Schematic representation of strategies used for microproteomics analysis using Liquid MicroJunction (LMJ) . The upper panel shows methods to define regions of interest (ROIs) according to highlighted regions,…
Benign thyroid nodules Malignant thyroid nodules Follicular adenoma (FA) Conventional variant papillary thyroid carcinoma (cvPTC) Hyperplastic (Hp) Follicular variant papillary thyroid carcinoma (fvPTC) Hashimoto’s thyroiditis (HT) Uncertain malignant potential (UMP)…
Fig. 1 Sample stocking procedure for ITO glass slides with mounted tissue 3.1.2 Tissue Preparation for MALDI-MSI 1. Following removal from the freezer, the ITO glass slides with mounted…
Fig. 1 Chemical structures of nonionic surfactants; (a) n-Octyl ß-d-glucopyranoside (OcGlu), (b) N-Octyl 1-thio-ß-d-glucopyranoside (OcThio), (c) N-Decyl ß-d-maltoside (DDM), (d) N-Octanoyl-N-methylglucamin (MEGA-8) Concentrations of OcGlu higher than 0.1% (up to…
© Springer Science+Business Media LLC 2017Laura M. Cole (ed.)Imaging Mass Spectrometry Methods in Molecular Biology161810.1007/978-1-4939-7051-3_16 16. The Future in Disease Models for Mass Spectrometry Imaging, Ethical Issues, and the Way Forward Rebecca E. Day1 and Ieva Palubeckaite1…
Fig. 1 Basic workflow of an imaging experiment with key focus areas; sample collection, sample preparation, choice of organic matrix , mode of application, and finally choice of mass spectrometer…
Fig. 1 Deposition of discrete matrix spots onto a fingermark sample and subsequent MALDI MS profiling showing how chemical differences can be observed between the selected areas 3.3.2 Spraying…
Fig. 1 MALDI-MS images of a cross section of untreated human skin (with the stratum corneum at the top of each image), acquired at a spatial resolution of 30 μm…
© Springer Science+Business Media LLC 2017Laura M. Cole (ed.)Imaging Mass Spectrometry Methods in Molecular Biology161810.1007/978-1-4939-7051-3_1 1. “A Future Amalgamation Between the Scientist and the Clinician?” Sarah Haywood-Small1 (1) Biomolecular Sciences Research Centre, Sheffield Hallam University,…
