Clinical indication Typical brain perfusion SPECT findings Differential diagnosis in dementia (Borghesani et al. 2010) Alzheimer’s disease (AD) Hypoperfusion of bilateral temporoparietal association cortices (often asymmetric) with characteristic sparing of…
[11C]Clorgyline [11C]Harmine [11C]Befloxatone Selectivity Excellent (Fowler et al. 1987) Excellent (Bergstrom et al. 1997b) Excellent (Dolle et al. 2003) Reversibility Not reversible (Fowler et al. 1987) Highly reversible (Ginovart…
Frame duration[s] 5 10 30 Number of frames 24 12 2 The advantageous short half-life of the tracer (122 s) enables the performance of multiple image acquisition scans in rapid…
where C(18F) is the total fluorine activity measured in the tissue, which is determined directly in the PET; C(FDG) is the concentration of free FDG in the tissue, calculated from…
Fig. 19.1 Effect of cocaine dependence on [11C]MRB binding in humans. BP ND (binding potential) values were compared between healthy control and cocaine-dependent individuals 19.3.1.2 Duration of Abstinence Effect on…
Fig. 8.1 Beta amyloid (Aß) processes from soluble amyloid precursor protein (s-APP) to different forms of Aß with their possible interaction with the nerve terminal (synapse) 8.2 Molecular Imaging The…
Fig. 10.1 Simplified diagram of a striatal dopaminergic synapse. On the presynaptic side, potential markers for imaging of the integrity of dopaminergic neurons in humans are shown. [18F]FDOPA and [18F]FMT…
Mouse fmol/mg protein a [ 11 C]TBZ % inj dose/g b Striatum 1,345 4.96 Thalamus 111 2.06 Hippocampus 141 2.01 Hypothalamus 411 2.96 Pons-medulla 167 1.96 Cortex (frontal) 115 1.91…
Name Action Abbreviation Initial publication [18F]Cyclofoxy Antagonist, μOR, and κOR – Pert et al. (1984) [11C]Diprenorphine Antagonist, non-subtype selective DPN Luthra et al. (1985) [18F]Diprenorphine Antagonist, non-subtype selective FDPN Wester…
Fig. 22.1 11C-PK11195 PET images of microglial activation in patients with (a) Alzheimer’s disease, (b) motor neurone disease, (c) Parkinson’s disease, (d) multiple sclerosis 11C-PK11195 and 11C-DAA1106 PET have also…
