Management of Hodgkin Lymphoma
Fig. 3.1 Management of early stage cHL 3.6 Treatment of Advanced-Stage Disease ABVD (six to eight cycles) or escalated BEACOPP (six cycles) is recommended for advanced disease. ABVD is associated…
Use Case III: Imaging Biomarkers in Breast Tumours. Development and Clinical Integration
Genomic test Target Specimen requirements Technique Characteristics OncotypeDx 21 genes FFPE RT-PCR Recurrence score (0–100) predicts likelihood of recurrence at 10 years. Role in predicting response to adjuvant and neoadjuvant…
Imaging Biomarker Model-Based Analysis
S b is the measured signal intensity of the DWI with gradient factor attenuation b (s/mm2), and S 0 is the measured signal intensity in the absence of diffusion weighting…
Detecting Measurement Biases: Sources of Uncertainty, Accuracy, and Precision of the Measurements
where represents the number of biomarkers, is the sum of variances of all of the items, and is the variance of the total score provided by the instrument. This parameter…
MRI Preprocessing
in the image by computing a weighted average of surrounding pixels using a robust similarity measure that takes into account the neighboring pixels surrounding the pixel being compared: (5.1)where w(x…
Use Case VI: Imaging Biomarkers in Diffuse Liver Disease. Quantification of Fat and Iron
Fig. 20.1 Illustrative example of a synthetic spectrum signal showing the water (highest peak, on the left) and the multiple fat peaks. On a 3 Tesla MR, the main fat…
Use Case V: Imaging Biomarkers in Musculoskeletal Disorders
Fig. 19.1 Density analysis of the proximal femur with QCT. (a) Coronal cross section where neck and trochanteric voxels have been highlighted in white. (b) Cortical (green contours) and trabecular…
A Proposed Imaging Biomarkers Analysis Platform Architecture for Integration in Clinics
Fig. 14.1 Main features of the different imaging biomarkers platform architectures existing nowadays 14.4 A Proposed Architecture The ideal solution would consist on a platform covering the features mentioned in…
Introduction to the Stepwise Development of Imaging Biomarkers
Fig. 2.1 Healthcare cycle and imaging biomarkers’ main hallmarks Radiology approaches are based on the interaction of energy and living organisms to analyze tissue noninvasively, revealing properties relevant to detection,…
Pearls and Pitfalls in Gold Standards and Biological Correlation
Fig. 12.1 A T2w fast spin echo image of the liver demonstrating geographic variation of fibrosis. Clearly biopsies obtained at location 1 and 2 are likely to differ considerably in…
