Defining the Biological Basis and Clinical Question (Proof of Concept); Looking for the Interrelationship (Proof of Mechanism)

Oct 18, 2017 by in GENERAL RADIOLOGY Comments Off on Defining the Biological Basis and Clinical Question (Proof of Concept); Looking for the Interrelationship (Proof of Mechanism)

Fig. 3.1 Example of a native coronary artery (CAC) scan acquired by multidetector CT in a 62-year-old male asymptomatic subject. (a) Three-dimensional volume-rendered display demonstrating the distribution of the calcified…

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Imaging Biomarker Measurements

Oct 18, 2017 by in GENERAL RADIOLOGY Comments Off on Imaging Biomarker Measurements

Fig. 8.1 Texture analysis of gadoxetic acid-enhanced MR images in patient with chronic liver disease. This figure shows differences in the GLCM according to the severity of liver fibrosis. Second-order…

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Imaging Biomarker Structural Analysis

Oct 18, 2017 by in GENERAL RADIOLOGY Comments Off on Imaging Biomarker Structural Analysis

(6.1) Equation 6.1 gives the relationship between the number of contour boxes (N), the corresponding box size (λ), the box-counting fractal dimension parameter (D), and a proportionality constant (k). An…

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Imaging Biomarkers in Clinical Trials

Oct 18, 2017 by in GENERAL RADIOLOGY Comments Off on Imaging Biomarkers in Clinical Trials

The role in a clinical trial Imaging biomarker type How widely used Comments Determinate eligibility Morphologic imaging (e.g., X-ray, mammography, CT, MRI) Whole-body FDG-PET Almost universal Established biomarkers Optimize patient…

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Imaging Biobanks, Big Data, and Population-Based Imaging Biomarkers

Oct 18, 2017 by in GENERAL RADIOLOGY Comments Off on Imaging Biobanks, Big Data, and Population-Based Imaging Biomarkers

© Springer International Publishing Switzerland 2017Luis Martí-Bonmatí and Angel Alberich-Bayarri (eds.)Imaging Biomarkers10.1007/978-3-319-43504-6_13 13. Imaging Biobanks, Big Data, and Population-Based Imaging Biomarkers Annalisa Mantarro1  , Paola Scalise1   and Emanuele Neri1   (1) Diagnostic and Interventional Radiology – Department of Translational Research…

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