Demyelinating lesions can be pathologically heterogeneous, depending on the degree of inflammation, membrane disruption, and type of cellular damage. Demyelinating lesions are more frequently associated with increased diffusion of water…
Diffusion sensitized MRI (dMRI) provides several useful metrics for the detection and characterization of traumatic brain injury (TBI).1 This chapter discusses applications of directionally nonselective dMRI techniques, such as diffusion…
Cytotoxic edema is seen within minutes to hours on diffusion weighted images (DWI) with sensitivity and specificity of 88 to 100% and 86 to 100%, respectively. Cortical watershed infarcts are…
Several forms of edema have been identified under the larger rubric of “brain edema.” These generally fall into the cellular or extracellular forms. Cellular edema denotes cytotoxic edema (CE). Extracellular…
Eloquent brain function emerges from the coordinated activity of multiple cortical and subcortical brain regions; the white matter defines a supporting network for the efficient transfer of information of these…
Diffusion based imaging strategies is sensitive to more subtle age-related changes in white matter integrity, and these methods may enable the differentiation of normal adult aging from mild cognitive impairment…
The pattern of evolving hematomas on conventional magnetic resonance imaging (MRI) is well documented but remains somewhat complex, and its interpretation is further complicated by diffusion weighted imaging (DWI). T2…
Physics In diffusion imaging, directional diffusion gradients are applied to a T2-weighted (spin-echo) echo-planar imaging (EPI) sequence before and after a 180-degree refocusing pulse. Water protons moving freely through these…
Diffusion weighted imaging (DWI) is the method of choice for the detection of spinal cord infarction. Diffusion tensor imaging (DTI) can be helpful for differentiating ependymoma from astrocytoma in adults….
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