In contrast to MRI, which gives a pictorial representation of body cross sections, MRS yields a “spectrum” of peaks at different radiofrequencies (“chemical shifts”). The chemical shift that results from…
Fig. 16.1 FDG-PET scan showing serial axial images and surface-rendered z-score maps of significant hypometabolism relative to a normal control database showing selective mesial occipital hypometabolism in a patient with…
Scan type Radiotracer Participants Main findings Reference SPECT 123I-IMP 1 ALS-FTD 1 HC Marked loss of frontotemporal uptake Sawada et al. (1988) 17 ALS (1 FU after 9 months); 15…
Fig. 48.1 Ligand-gated ion channels are probably the most relevant targets for general anaesthetics. A dark green or pink spot indicates significant potentiation or inhibition, respectively, of agonist actions at…
Authors N Diagnosis Time since insult (month(s)) Main findings Levy et al. (1987) 7 UWS 1–72 60 (53–67 %) decrease in metabolism DeVolder et al. (1990) 7 UWS 1–4 53…
Fig. 19.1 Example of mediastinal and cardiac region of interest (ROI) on anterior planar image. The left ventricular ROI was drawn including the ventricular cavity (H), and a rectangular ROI…
Fig. 11.1 In the SPM analysis the coloured clusters label the significantly lower α4β2*-nAChR availability by assessment of the 2-FA distribution volume ratio (2-FA-DVR) in AD and MCI patients (pilot…
Accurate diagnosis of Aβ pathology Prognosis of conversion to AD Assessment of the spatial and temporal pattern of Aβ deposition and its relation to disease progression, cognitive decline and other…
Fig. 42.1 (a) Gadolinium enhanced T1-weighted MRI revealing recurrence of an anaplastic oligoastrocytoma. (b) 99mTc-Tetrofosmin brain SPECT revealing increased tracer uptake in the corresponding area Fig. 42.2 (a) T1-weighted MRI…
