Radiology Key

Fig. 10.1 Key factors for successful therapy management with targeted agents [5] Adverse Event Management Targeted therapies such as sunitinib and everolimus have distinct typical adverse event profiles which differ to…

Fig. 8.1 Upstream activation of the mTOR signaling pathway and consequences of mTORC1 inhibition using everolimus in pancreatic neuroendocrine tumors Illustrations Genetic diseases associated with the development of digestive neuroendocrine tumors.Neuroendocrine…

Grade Mitotic per 10 high-power microscopic fields (HPF) Proliferative index/Ki-67 index (%) Low grade (G1) <2 ≤2 Intermediate grade (G2) 2–20 3–20 High grade (G3) >20 >20 Aim of Surgery…

18. Zitzmann K, Ruden JV, Brand S et al (2010) Compensatory activation of Akt in response to mTOR and Raf inhibitors—a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease….

Publication Chemotherapy Number of patients RR (%) PFS (months) OS (months) P value For RCT for OS Broder and Carter [1] STZ 52 50 – –  Moertel et al. [16] STZ 42…