Fig. 1 Scheme illustrating the principle of pretargeting: a the biotinylated antibody binds to the antigen expressed at the surface of the tumor cell, b binding of avidin with high affinity…

Fig. 1 a Otoscopic view of the myriongotomy tube of the left tympanic membrane before positioning of the applicator tube. b Otoscopic view of the ideal position of the applicator tube…

Fig. 1 WBS (a) and chest CT (b) performed after the 1st administration of 3.7 GBq of 131I ; WBS (c) and chest CT (d) performed after the 4th administration of 3.7 GBq…

Fig. 1 Serial whole-body scans after intrathecal injection of 0.5 mCi of In-111 DTPA via an Ommaya reservoir (a), or via lumbar puncture (b). Patency of CSF is demonstrated in both cases…

Peptide Receptor types/subtypes Tumor expression Somatostatin sst1, sst 2 , sst3, sst4, sst5 Neuroendocrine tumors (gastroenteropancreatic tumors), lymphoma, paraganglioma, carcinoids, breast, brain, renal, small cell lung cancer, medullary thyroid cancer…

Fig. 1 Intraperitoneal carcinomatosis with ascites 5 weeks after i.p. injection of MDA-MB435S cells expressing mutant E-cadherin into nude mice. a Section of an i.p. nodule (H&E staining) with tumour cells…

Fig. 1 Whole-body 111In-octreotide scintigraphy in a patient with lung and bone metastases from papillary thyroid cancer (from Stokkel et al. (2004)—Fig. 1) Two studies concluded that octreotide scintigraphy has a lower…

Fig. 1 Overall survival (Kaplan–Meier method) of the 185 included patients; the 6 month, 1- and 2-year overall survival were 60, 46 and 23 %, respectively (Zanzonico and Divgi 2008) (figure reproduced with…

Fig. 1 Bispecific pretargeting procedure. After the bsMAb is injected, it will localize in the tumor. In this example, the bsMAb has 2 binding arms for the tumor antigen, with monovalent…

Antibody Type Trials 3F8 (Cheung et al. 2012b) Murine IgG3 Phase I, II 14G2a (Murray et al. 1994) Murine Ig Phase I Ch14.18 (Yu et al. 2010) Chimeric IgG1 Phase…