© Springer-Verlag Berlin Heidelberg 2012Richard P. Baum (ed.)Therapeutic Nuclear MedicineMedical Radiology10.1007/174_2012_698 Pharma Considerations for Timely Development of Therapeutic Radiopharmaceuticals Adrian D. Nunn1 (1) Bracco Research USA Ltd, ⌦, 305 College Road East, Princeton, NJ 08540,…
Fig. 1 Coronal fused 124I PET/CT images showing restoration of radioiodine uptake after Selumetinib therapy Combining MEK inhibitor therapy with 124I dosimetry will help better select patients who will respond to…
Fig. 1 Arronax is a 70 meV cyclotron with multiparticle capacity. It can accelerate H− ions up to 70 MeV (tunable between 30 and 70 MeV) and extract them through two independent beam lines….
Fig. 1 Bar diagram showing the approximate frequencies of different neuroendocrine tumors referred for 68Ga-SR PET/CT imaging at our center. The most common indication for referral has been gastroenteropancreatic tumors (GEP-NETs)…
Ethylenediaminetetraacetic acid) for detection of blood–brain barrier integrity and 68 Ga-PLED (PLED N, N’-bis(pyridoxyl)ethylenediamine-N, N’-diacetic acid) or 68Ga-EDTA for renal function investigation. 68Ga-based targeting PET radiopharmaceuticals under phase III clinical trial…
Fig. 1 Elution profile of a 68Ge/68Ga generator where one fraction was 1 mL (fraction 1 = 0.3 mL, fraction 7 = 0.7 mL) for total eluted volume of 6 mL. The profiles for 68Ga elution and 68Ge breakthrough are similar….
Fig. 1 Biodistribution of Ga-citrate in normal rats. Ga-citrate (40 MBq) was injected into rats, and images were acquired at 60 min post-injection. 67Ga-citrate SPECT images are shown in a (before purification) and…
(1) where Ã(r S) is the cumulated activity (total number of nuclear decays integrated over a time period measured from injection to infinity) of the source. This general equation for…
Fig. 1 a SEM images after the labeling procedure: left MAA, right HSA spheres, ultrastructural analysis (Maus et al. 2011). b Stability tests in sterile water, 0.9% sodium chloride (NaCl), and human…
Fig. 1 CT-guided core-needle biopsy of the mediastinal tumor showed a moderately differentiated cellular neoplasm with syncytial growth pattern lacking mitotic activity. Immunohistochemically the tumor was positive for EMA (Fig. 1) while…
