The Clinical Epidemiology of Multiple Sclerosis
A comprehensive knowledge of the natural course and prognosis of multiple sclerosis is of utmost importance for a physician to make it affordable in simple descriptive terms to a patient…
NEUROLOGICAL IMAGING
Variants of Multiple Sclerosis
The classic multiple sclerosis variants including Devic’s neuromyelitis optica (NMO), Balo’s concentric Sclerosis, Schilder’s disease, and Marburg MS are both interesting and instructive from a disease pathophysiology perspective. Although rare,…
The Use of MR Imaging as an Outcome Measure in Multiple Sclerosis Clinical Trials
MR imaging is an integral part of multiple sclerosis (MS) clinical trials. It provides the primary efficacy outcome of preliminary proof-of-concept studies and important corroborating data as secondary and exploratory…
MR Relaxation in Multiple Sclerosis
This article provides an overview of relaxation times and their application to normal brain and brain and cord affected by multiple sclerosis. The goal is to provide readers with an…
The Clinical Epidemiology of Multiple Sclerosis
A comprehensive knowledge of the natural course and prognosis of multiple sclerosis is of utmost importance for a physician to make it affordable in simple descriptive terms to a patient…
Brain Atrophy Assessment in Multiple Sclerosis: Importance and Limitations
The use of MR imaging–derived methods to provide sensitive and reproducible assessments of brain volume (eg, to estimate atrophy) has increased the interest in this measure as a reliable indicator…
MR Image Postprocessing for Multiple Sclerosis Research
Computerized image analysis is becoming more routine in multiple sclerosis research. This article reviews the common types of task that are performed when producing quantitative measures of disease status, progression,…
Conventional MR Imaging
Conventional MR imaging refers to techniques that are readily available and widely used in the diagnosis and monitoring of individuals with multiple sclerosis (MS). MR imaging is helpful in establishing…
Basic Principles of Magnetic Resonance Imaging
Magnetic resonance (MR) imaging has become the dominant clinical imaging modality with widespread, primarily noninvasive, applicability throughout the body and across many disease processes. The flexibility of MR imaging enables…
Immunologic Mechanisms of Multiple Sclerosis
Multiple sclerosis is widely recognized as the most commonly identified cause of progressive neurologic disability in young adults throughout the developed world. The disorder is clinically suspected when patients experience…
