(1) Cleveland Clinic, Emeritus Staff, Cleveland, OH, USA KeywordsDetectorsBlock detectorsPETPET/CTPET/MRAnimal scanner Background The detection and measurement of radiation is based on the interaction of radiations with matter discussed in…
(1) Cleveland Clinic, Emeritus Staff, Cleveland, OH, USA KeywordsImage reconstructionFiltered backprojectionIterative methodsMLEMOSEMPartial volume Introduction Projection data acquired in two-dimensional (2D) mode or three-dimensional (3D) mode are stored in sinograms…
(1) Cleveland Clinic, Emeritus Staff, Cleveland, OH, USA KeywordsCyclotronTarget processingRadionuclide productionRadionuclide yield Introduction Nearly 3700 nuclides are known to exist, of which approximately 280 are stable and the remainder…
(1) Cleveland Clinic, Emeritus Staff, Cleveland, OH, USA KeywordsNRC regulationsRadiation protection10CFR2010CFR35DOT NRC Regulations for PET Radiopharmaceuticals Until 2005, the Nuclear Regulatory Commission (NRC) regulated only by-product materials that were…
(1) Cleveland Clinic, Emeritus Staff, Cleveland, OH, USA KeywordsAbsorbed doseTumor uptake 82Sr–82Rb generator Estimated Absorbed Dose from Intravenous Administration of 18F-FDG and 82Rb-RbCl in Humans The dose estimate D…
(1) Cleveland Clinic, Emeritus Staff, Cleveland, OH, USA KeywordsPET centerSite planningShieldingCost Introduction PET/CT has become one of the most common and useful modalities for detection and monitoring of treatment…
(1) Cleveland Clinic, Emeritus Staff, Cleveland, OH, USA KeywordsReimbursementCPTHCPCSICD-10CMS Background Healthcare providers (physicians, hospitals, clinics, etc.) operate and are sustained by the reimbursement or payment for care they provide…
(1) Cleveland Clinic, Emeritus Staff, Cleveland, OH, USA KeywordsPET radiopharmaceuticalsSynthesisSynthesis boxQuality control Introduction PET radiopharmaceuticals are uniquely different from SPECT radiopharmaceuticals in that the former have radionuclides that are…
(1) Cleveland Clinic, Emeritus Staff, Cleveland, OH, USA KeywordsPET/CT proceduresWhole-body imagingMyocardial imaging 18F-FDG 18F-Florbetapir 82Rb-RbCl Introduction In this chapter, different protocols for common PET procedures are described to provide…
(1) Cleveland Clinic, Emeritus Staff, Cleveland, OH, USA KeywordsFDA regulationsCompoundingPET radiopharmaceuticalsLegal requirements Food and Drug Administration Since 1975, the clinical use of all radiopharmaceuticals in humans has been regulated…
