Langerhans Cell Histiocytosis Edward C. Halperin HISTORICAL BACKGROUND Paul Wilhelm Heinrich Langerhans (1847-1888) was born in Berlin. His father and his two brothers were physicians. While still an undergraduate, Langerhans…
Endocrine, Aerodigestive Tract, and Breast Tumors Line Claude Cécile Nozières ADRENOCORTICAL CARCINOMA Histology Adrenocortical carcinoma (ACC) is an aggressive cancer originating in the cortex of the adrenal gland. This chapter…
Germ and Stromal Cell Tumors of the Gonads and Extragonadal Germ Cell Tumors Christian Carrie Edward C. Halperin Gonadal or extragonadal germ cell tumors (GCTs) represent less than 2% of…
Liver Tumors in Children Bow-Wen Chen Stella Y. Tsai Skye H. Cheng Andrew T. Huang INTRODUCTION Childhood primary tumors of the liver are rare. Of these, about two thirds are…
Wilms Tumor John A. Kalapurakal Edward C. Halperin HISTORY The first description of a Wilms tumor was from Thomas F. Rance (1) in his 1814 report “Case of Fungus Haematodes…
Soft Tissue Sarcomas Other Than Rhabdomyosarcoma; Desmoid Tumor Kenneth B. Roberts Edward C. Halperin The word sarcoma is derived from the Attic Greek word σ&aacgr;ρκωµα or sarkoma meaning a fleshy…
Rhabdomyosarcoma Shannon M. MacDonald Alison M. Friedmann Nancy J. Tarbell Louis S. Constine Rhabdomyosarcoma (RMS) is a highly malignant neoplasm that arises from embryonal mesenchyme with the potential for differentiating…
Osteosarcoma, Chordoma, and Chondrosarcoma Shiao Y. Woo Edward C. Halperin Osteosarcoma is the most common primary malignant bone tumor in children. The tumor derives from boneforming mesenchyme (1, 2, 3,…
Ewing Sarcoma Karen J. Marcus Torunn Yock Nancy J. Tarbell James Ewing (1866-1943) first described the bone tumor that bears his name in 1921 (1). He observed that the malignancy…
Non-Hodgkin Lymphoma Mary S. Huang Nancy J. Tarbell Howard J. Weinstein Malignant lymphoma was described by Hodgkin in 1832 (1) and was distinguished from leukemia by Virchow in 1845 (2)….
