Multiple sclerosis (MS) pathology is originally defined by the presence of focal white matter lesions, characterized by inflammation, primary demyelination, and reactive glial scaring. More recently, however, it became clear…
This article explores the role of high-field (HF) MR imaging in medicine. It analyzes advantages of HF MR imaging in application to human subjects and how best they can be…
Conventional MR imaging is, at present, the most important paraclinical modality for assessing the risk of MS in patients with acute demyelinating ON and for monitoring the progression of disease….
MR imaging has had a major impact on understanding the dynamic neuropathologic findings of multiple sclerosis (MS), early diagnosis of the disease, and clinical trial conduct. The next 10 years…
This article provides an overview of relaxation times and their application to normal brain and brain and cord affected by multiple sclerosis. The goal is to provide readers with an…
Multiple sclerosis is a diffuse disease of the central nervous system, and MRI of the spinal cord is highly recommended in the clinical evaluation of patients suspected of having multiple…
Proton magnetic resonance spectroscopy ( 1 H-MRS) provides tissue metabolic information in vivo. This article reviews the role of MRS-determined metabolic alterations in lesions, normal-appearing white matter, gray matter, and…
A variable effectiveness of reparative and recovery mechanisms following tissue damage is among the factors that might contribute to explaining resolution of symptoms and maintenance of a normal level of…
We introduce the fundamental aspects of MT, of MT MR imaging, and the respective analysis techniques. We then review the applications of MT MR imaging to multiple sclerosis. Finally we…
Diffusion tensor (DT) MR imaging is able to detect and quantify multiple sclerosis (MS)–related tissue damage within and outside T2-visible lesions. DT MR imaging has also been shown to be…
