Fig. 1 Comparison of papillary thyroid microcarcinoma (PTMC) according to tumour size: In 349 patients with PTCM the tumour size was significantly correlated with the prevalence of lymph node metastasis (p < 0.01)…
Substance class Drug Available data Retinoids Retinoic acid Phase-I/II-studies and numerous observation studies Retinoid-X-receptor-ligand Bexarotene (300 mg) Phase-I/II-study (8 patients) Agonists of the “peroxisome-proliferator activated receptor gamma” (PPAR-g) Rosiglitazone Phase-I/II-study (10…
Fig. 1 Sodium iodide symporter Several anions are transported by NIS, namely, I, SeCN, SCN, ClO3, and NO3 (in descending order of affinity). NIS also transports technetium pertechnetate and rhenium perrhenate….
First author, year Country Patients enrolled (n) TNM Pathology (P/F) Type of surgery Dose (mCi) Follow-up time (mo) Definition of successful ablation Method of preparation Bal, 1996 India 149 TxNxMo…
5th Edition 6th Edition Supplement 7th Edition T1 Intrathyroidal tumour ≤1 cm Intrathyroidal tumour ≤2 cm Intrathyroidal tumour ≤1 cm (pT1a) idem Intrathyroidal tumour >1 and ≤ 2 cm (pT1b) T3 Intrathyroidal tumour…
where Co is the initial concentration (mCi/g) of I-131 in the lesion, and T1/2 is the effective half-life of activity in the lesion in hours. Thus, in order to determine…
Radionuclides PET SPECT Therapy (beta) Therapy (alpha) Short half-life Long half-life Short half-life Long half-life Readily available—worldwide access—GMP grade 18F 124I 99mTc 111In 131I 90Y – Available—local access only (64Cu)…
© Springer-Verlag Berlin Heidelberg 2012Richard P. Baum (ed.)Therapeutic Nuclear MedicineMedical Radiology10.1007/174_2012_698 Pharma Considerations for Timely Development of Therapeutic Radiopharmaceuticals Adrian D. Nunn1 (1) Bracco Research USA Ltd, ⌦, 305 College Road East, Princeton, NJ 08540,…
Fig. 1 Coronal fused 124I PET/CT images showing restoration of radioiodine uptake after Selumetinib therapy Combining MEK inhibitor therapy with 124I dosimetry will help better select patients who will respond to…
Fig. 1 Arronax is a 70 meV cyclotron with multiparticle capacity. It can accelerate H− ions up to 70 MeV (tunable between 30 and 70 MeV) and extract them through two independent beam lines….
