Models for Developing Radiopharmaceuticals for Therapy
Species Mouse Man Weight 20 g 70 kg Blood volume 2 ml 5 l GIT transit 20 h 40 h Heart beat 600/min 65/min Respiration 160/min 12/min Renal blood flow 75 %/min 15 %/min Adapted from: (Davies and…
of Renal Cancer
Fig. 1 Patient with metastatic ccRC treated over a year with 3 courses of fractionated radioimmunotherapy with 131I-labeled chimeric G250. Anterior and posterior whole body images obtained 2 days after scout (A),…
Therapy of Hyperthyroidism in Graves’ Disease
Fig. 1 Longitudinal (a) and transverse (b) images of the left thyroid lobe on ultrasound. The maximum length (L), width (W), and depth (D) of each lobe are measured to calculate…
Use of Radionuclides and Treatment of Meningiomas
Fig. 1 In order to facilitate LR administrations, a catheter into the SCRC and connected with a subcutaneous reservoir is permanently implanted during surgical procedure The rationale for intracavitary administered therapies…
Meta Iodobenzylguanidine Therapy
Fig. 1 Discordant mIBG/FDG PET imaging. Patient with metastatic phaeochromocytoma, referred for mIBG therapy. a 131I mIBG anterior whole body imaging shows focal abnormal uptake in the superior thoracic spine and…
Radioimmunotherapy of Non-Hodgkin Lymphoma with 90-Y-Labeled Anti-CD22 Antibody, Epratuzumab Tetraxetan
Fig. 1 Images of a patient with a follicular lymphoma relapse. a FDG-PET recorded before RIT showed an abnormal focus in the mediastinum. b FDG-PET demonstrated a metabolic complete response as…
for Nuclear Medicine Therapy
Generic name Trade name Agent/Target Cancer indication Approval Unconjugated Rituximab Rituxan Chimeric anti-CD20 IgG1 B cell lymphoma 1997 Trastuzumab Herceptin Humanized anti-HER2 IgG1 Breast 1998 Alemtuzumab Campath-1H Humanized anti-CD52 CLL…
Lymphoma High Dose Therapy
Aggressive histologic types Diffuse large B cell lymphoma Mantle cell lymphoma Lymphoblastic lymphoma CNS lymphoma Immunoblastic lymphoma AIDS-related lymphoma Indolent histologic subtypes Follicular lymphomas Diffuse small lymphocytic lymphomas/CLL Lymphoplasmacytic lymphomas…
Therapy of Brain Tumors
Age/gender Histology/location Treatment before/after targeted RT* Total activity (MBq)/radionuclide Barthel index before/at the end of targeted RT Survival after initiation of targeted RT Overall sur-vivala Glioblastomas 37/F G/fL S-R-C 375/213Bi…
of Lymphoma with 131I-Chimeric Monoclonal Antibodies
© Springer-Verlag Berlin Heidelberg 2012Richard P. Baum (ed.)Therapeutic Nuclear MedicineMedical Radiology10.1007/174_2012_734 Treatment of Lymphoma with 131I-Chimeric Monoclonal Antibodies J. Harvey Turner1 (1) School of Medicine and Pharmacology, Department of Nuclear Medicine, The University of…
