Medicine Dose Assessment
(1) where = absorbed dose rate to a target region of interest (Gy/sec or rad/hr) A S = activity (MBq or μCi) in source region S y i = number of radiations…
Receptor Radionuclide Therapy of Neuroendocrine Tumors Expressing Somatostatin Receptors
Fig. 1 Well-differentiated neuroendocrine tumor (NET) of pancreatic tail, s.p. extended pancreatectomy and partial omentectomy, initial tumor stage (UICC) pT2 (Ø 3.2 cm) pN1 (6/12) cM1 R0, LX VX, G2, proliferation rate…
Dosimetry, Radiobiology, and the Previously-Treated Patient
(1) Since lethal lesions are Poisson-distributed across a cell population, the probability that a large population of cells will undergo a certain number of lethal lesions (i.e., the surviving fraction,…
Lymphoma: Radioimmunotherapy Using Iodine-131 Labeled Murine Anti-CD20 Antibodies (131I-Tositumomab and Tositumomab, “Bexxar”)
Fig. 1 2D representation of the CD20 antigen (previously known as “B1”). Note that antibodies used in RIT bind to the extracellular domain. This figure was published in American Journal…
by Low Dose Radiation Effects: Low-Dose Cancer Risk Modeling Must Recognize Up-Regulation of Protection
Fig. 1 Scheme of particle distribution in tissues. Shown are several electrons and an alpha particle. Clearly, total energy absorbed per unit mass, i.e., dose correlates with the number of particles…
Radionuclides: Production, Physical Characteristics, and Applications
Fig. 1 A schematic comparison of energy types for therapeutic radionuclides (Srivastava 2012) In general, all high-LET emitters are much more effective for small lesions and for micrometastatic disease. For example,…
Concepts and Procedures
Global N = 206 Group under analysis All grades Grade 4 Radiation pneumonitis 206 treatments 1 (0.4 %) 0 GI ulcers 215 procedures 3 (1.4 %) 0 REILD (global) 206 treatments 24 (11 %)…
Generator-Based Radiopharmaceuticals for Therapy
Fig. 1 Publications describing rhenium-188 radiopharmaceutical development and clinical trials (data from MedLine) From a clinical perspective, radionuclide therapy has a high impact in the treatment of benign diseases, such as…
Approaches: Combined Local and Multimodal Strategies in the Treatment of Complex Neuroendocrine Liver Metastases
Type of disease Strategy Goal Single spots “rule of five” <5 cm diameter; <5 spots RFTA, (LITT), MW Complete destruction A0-ablation/curation Small hypervascularized lesion TAE with embozene; alternative: DC-Beads Complete destruction/curation Big…
Use of Dosimetry in the Planning of Patient Therapy
Here D β is the beta dose in rad, C is the concentration of the nuclide in the tissue in microcuries per gram, E β is the mean energy emitted…
