Hodgkin Lymphoma
Stage Areas involved I One lymph node region or lymphoid structure II ≥2 lymph node regions on the same side of the diaphragm III Lymph nodes on both sides of…
Radiological Imaging in Lymphoma
Fig. 4.1 Staging intravenous contrast-enhanced CT in a 26-year-old female presenting with cervical lymphadenopathy with biopsy demonstrating Hodgkin lymphoma; (a) axial section and (b) coronal reformat demonstrate multiple pathologically enlarged…
18F-FDG PET/CT in Hodgkin’s Lymphoma
Uptake Score No uptake 1 Uptake less than or equal to the mediastinum 2 Uptake greater than the mediastinum but less than or equal to the liver 3 Uptake moderately…
Pathology of Hodgkin Lymphoma
Fig. 2.1 Lymphocyte predominant (LP) cells in nodular lymphocyte predominant Hodgkin lymphoma (LPHL) show the typical popcorn morphology (arrows and inset; ×400 and ×600) (haematoxylin and eosin (H&E) stain). The…
Management of Hodgkin Lymphoma
Fig. 3.1 Management of early stage cHL 3.6 Treatment of Advanced-Stage Disease ABVD (six to eight cycles) or escalated BEACOPP (six cycles) is recommended for advanced disease. ABVD is associated…
Use Case III: Imaging Biomarkers in Breast Tumours. Development and Clinical Integration
Genomic test Target Specimen requirements Technique Characteristics OncotypeDx 21 genes FFPE RT-PCR Recurrence score (0–100) predicts likelihood of recurrence at 10 years. Role in predicting response to adjuvant and neoadjuvant…
Imaging Biomarker Model-Based Analysis
S b is the measured signal intensity of the DWI with gradient factor attenuation b (s/mm2), and S 0 is the measured signal intensity in the absence of diffusion weighting…
Detecting Measurement Biases: Sources of Uncertainty, Accuracy, and Precision of the Measurements
where represents the number of biomarkers, is the sum of variances of all of the items, and is the variance of the total score provided by the instrument. This parameter…
MRI Preprocessing
in the image by computing a weighted average of surrounding pixels using a robust similarity measure that takes into account the neighboring pixels surrounding the pixel being compared: (5.1)where w(x…
Use Case VI: Imaging Biomarkers in Diffuse Liver Disease. Quantification of Fat and Iron
Fig. 20.1 Illustrative example of a synthetic spectrum signal showing the water (highest peak, on the left) and the multiple fat peaks. On a 3 Tesla MR, the main fat…
