Radiology Key

Fig. 1 a Left: DNA Binding Domains (DBD) of the heterodimer USP/EcR on the DNA target, an inverted repeat separated by one base (IR1). PDB ID: 2HAN. Right: DBDs of…

Fig. 1 The core SMRT/NCoR complex is recruited to chromatin through the ligand-binding domains of unliganded-nuclear receptors to repress transcription. The SMRT/NCoR complex transiently assembles with chromatin modifying enzymes and…

Fig. 1 Classical action of the glucocorticoid signaling mediated by the GR. Unliganded receptor is located in the cytosol associated with several heat shock and other chaperone proteins including HSP90,…

Fig. 1 The UspDBD/EcRDBD heterocomplex bound to an idealized consensus IR-1 (Devarakonda et al. 2003) (a) and to the natural hsp27 pal (Jakób et al. 2007) (b). The structure of the UspDBD/EcRDBD…

Fig. 1 Chemical structures of the corticosteroid receptor agonist and antagonist ligands discussed This chapter will explore the structural determinants of function within the corticosteroid receptors, primarily focusing on the…

Fig. 1 Steroidogenic pathways (both traditional and backdoor) responsible for the synthesis of androgens and estrogens from cholesterol. HSD-Hydroxysteroid dehydrogenase All of the subsequent steps in androgen and estrogen synthesis…

Fig. 1 Sequence logos for classical and selective AREs. Classical AREs resemble inverted repeats of the 5′-AGAACA-3′-like motif spaced by three nucleotides, while selective AREs resemble direct repeats of the…

Fig. 1 MAGE-A11 amplification of human AR transcriptional activity by linking AR dimers. AR dimerization is mediated by the DNA binding domain and the androgen-dependent AR N/C interaction (Wong et al….