Malignant Melanoma
Primary tumor (T) TX Primary tumor cannot be assessed (e.g. curettaged or severely regressed melanoma) T0 No evidence of primary tumor Tis Melanoma in situ T1 Melanomas 1.0 mm or…
Radiobiology and Radiation Dosimetry in Nuclear Medicine: Therapy, Diagnosis, and Considerations for Sensitive Populations
Fig. 6.1 Conventional dose-rate effect for cell killing as the dose rate is lowered from 150 to 1.6 cGy/min. The dashed curves represent the best fit to the data set…
Lung and Mediastinal Tumors
Group T category N category M category Occult carcinoma TX N0 M0 Stage 0 Tis N0 M0 Stage IA T1a N0 M0 T1b N0 M0 Stage IB T2a N0 M0…
Gynecologic Cancers
Fig. 22.1 Observed survival rates for 15,070 cases with carcinoma of the cervix uterus. Data from the National Cancer Data Base (Commission on Cancer of the American College of Surgeons…
Pediatric Cancers
Cancer group ACCIS (%) SEER (%) Total 72 75 Leukemias 73 74 Lymphomas and reticuloendothelial neoplasms 84 83 CNS and miscellaneous intracranial and intraspinal neoplasms 64 66 Sympathetic nervous system…
Tumors of the Liver and Biliary Tract
Fig.16.1 Survival stratified according to stage grouping for liver tumors. (Data from Vauthey JN, Lauwers GY, Esnaola N, et al. A simplified staging for hepatocellular carcinoma. J Clin Oncol. 2002;20:1527–36….
Pancreatic Cancer
Pathologic features Incidence (%) Ductal adenocarcinoma 80–90 Intraductal papillary mucinous neoplasm 3–5 Pancreatic neuroendocrine tumor 3–4 Serous cystadenoma 1–2 Mucinous cystic neoplasm 1–2 Acinar cell carcinoma 1–2 Solid pseudopapillary neoplasm…
The Cancer Biology of Molecular Imaging
Radiotracer Function [18F]FDG Glycolysis 18F-FLT Proliferation [11C]MET, 18F-FACBC Amino acid transport 18F-FDHT Androgen receptor 18F-FES Estrogen receptor Na124I NIS [11C]acetate Kreb’s cycle, FA syn 18F-MISO Hypoxia Hallmarks of Cancer There…
Multiple Myeloma
Fig. 8.1 Schematic representation of interactions between MM cells and bone microenvironment (right panel ) as compared to the physiological balance (left panel ). Dickkopf 1, a potent inhibitor of…
