Extracranial Stenosis: Endovascular Treatment
Stroke is the third-leading cause of death in the United States. It occurs in almost 700,000 people per year and cost an estimated $57.9 billion in 2006. Atherosclerotic disease is…
NEUROLOGICAL IMAGING
Chronic Ischemia and Neurocognition
Cognitive impairment from a major stroke as a consequence of carotid disease is an acknowledged clinical outcome; however, cognitive impairment without major stroke is open to discussion. The three recognized…
Mechanisms of Ischemic Stroke Secondary to Large Artery Atherosclerotic Disease
Atherosclerotic occlusive disease of the cervical and intracranial arteries leads to ischemic stroke through two separate, but interrelated, mechanisms: local thrombosis or embolism from atherosclerotic plaque, and hemodynamic failure (low…
Pathology of Atherosclerosis and Stenting
Atherosclerotic plaque at the carotid bifurcation is the primary cause of ischemic strokes and the degree of carotid stenosis is strongly associated with stroke risk in symptomatic patients. Stroke is…
Visualizing White Matter Pathways in the Living Human Brain: Diffusion Tensor Imaging and Beyond
Biologic connectionism holds as its central tenet that the cognitive, behavioral, and motor functions of the brain are derived from the complex interconnections of simple neural processing units. Much can…
The Role of Imaging in United States Courtrooms
The rapid evolution of brain imaging techniques has increasingly offered more detailed diagnostic and prognostic information about neurologic and psychiatric disorders and the structural and functional brain changes that may…
Imaging the Neurochemistry of Alcohol and Substance Abuse
Animal models of abuse and dependence have long suggested that chronic drug and alcohol exposure is associated with marked changes in neurochemistry. The development of PET and SPECT imaging now…
The Role of Imaging in United States Courtrooms
The rapid evolution of brain imaging techniques has increasingly offered more detailed diagnostic and prognostic information about neurologic and psychiatric disorders and the structural and functional brain changes that may…
Modeling Pain Circuits: How Imaging May Modify Perception
Pain is the unpleasant sensory experience following tissue damage or the threat of damage. The activation of cortical regions during noxious stimulation is believed a result of the negative affect…
Mood Disorders
Despite the prevalence of the mood disorders, the underlying neuropathology is still poorly understood. This article describes abnormalities in brain activation that have been reported in neuroimaging studies of patients…
