The classic multiple sclerosis variants including Devic’s neuromyelitis optica (NMO), Balo’s concentric Sclerosis, Schilder’s disease, and Marburg MS are both interesting and instructive from a disease pathophysiology perspective. Although rare,…
MR imaging is an integral part of multiple sclerosis (MS) clinical trials. It provides the primary efficacy outcome of preliminary proof-of-concept studies and important corroborating data as secondary and exploratory…
This article provides an overview of relaxation times and their application to normal brain and brain and cord affected by multiple sclerosis. The goal is to provide readers with an…
A comprehensive knowledge of the natural course and prognosis of multiple sclerosis is of utmost importance for a physician to make it affordable in simple descriptive terms to a patient…
The use of MR imaging–derived methods to provide sensitive and reproducible assessments of brain volume (eg, to estimate atrophy) has increased the interest in this measure as a reliable indicator…
Computerized image analysis is becoming more routine in multiple sclerosis research. This article reviews the common types of task that are performed when producing quantitative measures of disease status, progression,…
Conventional MR imaging refers to techniques that are readily available and widely used in the diagnosis and monitoring of individuals with multiple sclerosis (MS). MR imaging is helpful in establishing…
Magnetic resonance (MR) imaging has become the dominant clinical imaging modality with widespread, primarily noninvasive, applicability throughout the body and across many disease processes. The flexibility of MR imaging enables…
Multiple sclerosis is widely recognized as the most commonly identified cause of progressive neurologic disability in young adults throughout the developed world. The disorder is clinically suspected when patients experience…
Multiple sclerosis (MS) pathology is originally defined by the presence of focal white matter lesions, characterized by inflammation, primary demyelination, and reactive glial scaring. More recently, however, it became clear…
