Fig. 1 The AR-LBD used as an example to represent location of alternative binding sites of NRs. Standard view of AR-LBD followed by − 90° turn on x-axis and + 90° turn on…
Fig. 1 The domain organization of NHR’s The diagram reads N-terminus on the left, C-terminus on the right. The N-terminal domain (NTD) is intrinsically disorder and often binds cofactor proteins….
Fig. 1 a Left: DNA Binding Domains (DBD) of the heterodimer USP/EcR on the DNA target, an inverted repeat separated by one base (IR1). PDB ID: 2HAN. Right: DBDs of…
Fig. 1 The core SMRT/NCoR complex is recruited to chromatin through the ligand-binding domains of unliganded-nuclear receptors to repress transcription. The SMRT/NCoR complex transiently assembles with chromatin modifying enzymes and…
Fig. 1 Classical action of the glucocorticoid signaling mediated by the GR. Unliganded receptor is located in the cytosol associated with several heat shock and other chaperone proteins including HSP90,…
Fig. 1 The UspDBD/EcRDBD heterocomplex bound to an idealized consensus IR-1 (Devarakonda et al. 2003) (a) and to the natural hsp27 pal (Jakób et al. 2007) (b). The structure of the UspDBD/EcRDBD…
Fig. 1 Steroidogenic pathways (both traditional and backdoor) responsible for the synthesis of androgens and estrogens from cholesterol. HSD-Hydroxysteroid dehydrogenase All of the subsequent steps in androgen and estrogen synthesis…
Fig. 1 Sequence logos for classical and selective AREs. Classical AREs resemble inverted repeats of the 5′-AGAACA-3′-like motif spaced by three nucleotides, while selective AREs resemble direct repeats of the…
Fig. 1 MAGE-A11 amplification of human AR transcriptional activity by linking AR dimers. AR dimerization is mediated by the DNA binding domain and the androgen-dependent AR N/C interaction (Wong et al….
