Pulmonary neoplasm and lymphoproliferative disorders may present with diffuse lung abnormalities. The goal of this chapter is to discuss the various patterns of diffuse pulmonary neoplasm and lymphoproliferative disease and…
Sarcoidosis is an idiopathic disorder characterized by the presence of noncaseating granulomas, often found in relation to lymphatics, and involving many organs. It typically presents in patients less than 50…
DRUG-INDUCED LUNG DISEASE Drug-induced lung disease is often overlooked or misdiagnosed. The most common categories of drugs that result in lung disease include chemotherapeutic agents, cardiac medications, and antibiotics. Drug-induced…
HYPERSENSITIVITY PNEUMONITIS Hypersensitivity pneumonitis (HP) represents an immune reaction to inhaled organic antigens. The possible sources of these antigens are diverse and include microbes, animals, plant material, and various chemicals….
The incidence of pneumoconioses is decreasing in relation to other diffuse lung diseases, because of a greater emphasis on prevention in high-risk occupations. Because they often have HRCT findings that…
Vascular diseases of the lung may affect arteries, veins, and/or capillaries. They are primarily evaluated using modalities such as echocardiography, contrast-enhanced CT, or conventional angiography, but in selected cases, HRCT…
Connective tissue diseases (CTDs) may be associated with a variety of lung abnormalities. Most patients with CTD have extra-pulmonary manifestations but in some cases, lung abnormalities are seen in isolation…
PULMONARY ALVEOLAR PROTEINOSIS Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized pathologically by the accumulation of lipoprotein within alveoli. There are three different forms of the disease. Congenital PAP…
Focal or regional areas of decreased lung attenuation (i.e., increased lung lucency) can have a variety of causes and HRCT appearances. These include lung destruction due to emphysema, decreased lung…
Cigarette smoking is well known for its association with lung cancer, but diffuse lung disease is also an established cause of smoking-related morbidity. There are a variety of different manifestations…
