Radiology Key

Fig. 8.1 Sodium channel blocking agents improve neurological status of rodents with EAE. (a, b) Clinical scores (mean  ±  SEM) are shown for untreated C57/Bl6 mice with progressive EAE (inverted…

Fig. 5.1 Transplantation of oligosphere cells into md rats. Before transplantation, the oligosphere cells were transduced with retrovirus to express β-gal (a). Between 10 and 14 days after transplantation, a…

Fig. 10.1 MRI (left), MWF (middle) and Luxol fast blue myelin stain of post-mortem tissue (right) (figure from Laule et al. 2006) The number of myelin water imaging studies of…

Fig. 6.1 Schematic representation of the different strategies developed to enhance SC migratory potential in the CNS. Different approaches improved SC remyelination capacity whether directly by modifying SC properties, decreasing…

Fig. 1.1 In cell cultures, oligodendrocyte precursors (OPCs) develop through a series of stages that can be identified by cell-type-specific markers. (a) Immature oligodendrocyte precursors are largely bipolar cells that…

Scale Description Reference (A) Physician measured Disease specific Expanded (Kurtzke) Disability Status Scale (EDSS) 20-Step ordinal scale. Benchmark position despite poor metric properties Hobart et al. (2000) Multiple Sclerosis Functional…

Fig. 4.1 (a) Electron micrograph of myelinated axons and axons that have been remyelinated following ethidium bromide injection into the adult rat caudal cerebellar peduncle. The myelinated axons have clearly…

Indirect effects Active (consequences of molecular changes in immune cells exposed to systemic therapy) Passive (deletion of immune cells or blocking CNS access) Molecules expressed by modulated immune cells could…

Fig. 7.1 There are multiple considerations when designing the clinical translation of cell therapy. These include choosing the relevant therapeutic target(s) for the candidate disease, choosing the proper cellular platform,…